Hendrix Genetics Genomics Laboratory

Published on Feb. 20, 2018

Collaboration with Wageningen University to find disease resistance gene in chickens

Wageningen University and Hendrix Genetics recently collaborated on a project to identify a DNA region in chickens that may explain why some chickens are more disease-resistant than others. 

The focus of the findings is related to natural antibodies (NAb). Typically, antibodies are proteins that attack the pathogen which can be found in sick animals. But animals also have natural antibodies that can be found in a healthy individuals that have not been exposed to a pathogen. NAb inhibits and presents infection in the body and also activates other parts of the immune system to fight the pathogen. Studies have shown that high NAb levels in chickens are associated with better survivability and that NAb levels are inheritable.

Within our pure lines, we are running three field experiments with layers that have high or low NAb levels and measuring livability and production between the different groups. Hendrix Genetics has also worked with the university to find the DNA region on the chicken genome associated with NAb levels, which is most likely the TLR1A gene. This gene is part of a group of receptors that can detect certain characteristics of a bacteria or virus.

Overall, continued study of this field could mean better selection of increased disease resistance in our layer flocks. We are excited to be a part of this example of innovation and collaboration by providing animals and data for this research. 

R&D Farm brown chicken colleague layers
Click to read the full article from Wageningen